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14 Dec

Dual activation of the mu and, less potently, delta opioid receptors may be critical to tianeptine's mood-brightening and anxiolytic effect - a therapeutic action seemingly unaccompanied by the physiological tolerance and dependence that have plagued traditional opioids.

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Even after FDA approval, tianeptine/Stablon could be sold only cheaply due to generic competitors.Selective mu opioid agonists in the brain's "hedonic hotspots" typically induce euphoria.Selective kappa agonists typically induce dysphoria. The role of central delta opioid receptors is poorly understood.Tianeptine lacks any significant activity at monoamine transporters or neurotransmitter receptors.How it actually accelerates serotonin reuptake, both acutely and chronically, is unclear.